Many people cannot function properly without copious amounts of caffeine in their system on the daily basis. They drink cup after cup of coffee to open their eyes wider and wire up their systems. And after that coffee wears off and the dreaded “2PM slump” hits, everyone knows it’s time for a second round. Coffee has become a life source for many folks and science has now found a genetic reason why we all drink so much coffee.
A recent study found that a gene variation called PDSS2 makes people metabolize coffee slower — meaning they need less of it.
This gene variation is responsible for both lowering your caffeine cravings and making the coffee stay in your system for a prolonged time. People without the variation metabolize coffee at a normal/speedy rate — which means that are running for that second cup as you still ride the energy wave from the first.
Maybe they are just more sensitive to the chemicals inside of coffee, which would explain why those lucky people evolved to not need liquid gold. Oh, what we wouldn’t do to naturally wake ourselves up in the morning.
The study was conducted on 1,200 people from Italy and then replicated in a follow-up study in the Netherlands. All results point to people with the gene variation PDSS2 drinking significantly less coffee every day compared to those who don’t have the variation. While coffee consumption studies are not uncommon, finding a result like this pretty rare. Hopefully, in the future, we can be genetically modified to avoid that third or fourth cup in the office.